Tag: Exercise

Exercise and Cancer Cells: High-Intensity Exercise = High-Intensity Results [RESEARCH]

(Title image: Photo by Blocks Fletcher on Unsplash)

I am a huge proponent of exercise, both for prevention of cancer and its recurrence and in management of cancer treatment side effects, not to mention improving quality-of-life. Now a new study shows how even just one exercise session can have a powerful effect on cancer cells.

A randomized controlled trial conducted by researchers in Australia (Bettariga et al., 2025, Breast Cancer Res Treat) explored the effects of a single bout of vigorous activity (either weightlifting or interval training) on the production of anti-cancer myokines and investigated how blood drawn from study participants affected live cancer cells in the laboratory.

There has been a lot of research on the efficacy of exercise in reducing the risk of both developing cancer and preventing recurrence. However, this study focused exclusively on breast cancer survivors, which was important given that the physiology of survivors is affected by the treatments that they’ve gone through.

What was so gratifying to me was to see the significant effect of strenuous exercise. While the greatest benefit was seen from high-intensity interval training regarding its lethal effect on live breast cancer cells due to particularly high levels of a myokine called IL-6, the researchers stressed that strength training was likewise important as a cancer-fighting activity because building muscle through exercise also increased the amount of myokines circulating through the body.

The study participants engaged in strenuous exercise, but the program was created with noice exercisers in mind.
(Photo by Intenza Fitness on Unsplash)

It’s important to note that all thirty-two participants in this study were not exercising prior to joining the research group. Even so, they were able to tolerate the high intensity of the workouts. Keep in mind that “high intensity” is relative to the individual. That means strenuous exercise (for this study, reaching an effort level of at least a 7 or 8 on a scale of 1 to 10) will be different for a novice exerciser versus a highly-trained professional athlete.

So often, I encounter people who are willing to take a plethora of medications with considerable side effects, but roll their eyes when exercise is mentioned. Some people view physical activity as being only for those who are interested in looking a certain way or being mainly for those who have already reached a certain level of fitness.

Nothing could be further from the truth. Exercise is for everyone. We all start at different points; where exactly that is doesn’t matter. What does matter is that we are willing to exert enough energy to make a difference in our physiology and our well-being.

This is not “diet culture” or anything to do with body shaming. This is about doing what you can personally to increase your chances of a cancer-free life.

Survivors can talk to their healthcare team, show them this research and request that doctors lobby their insurance companies. Personal training, subsidized exercise equipment and gym memberships, fitness classes at cancer centers—all of these should be considered a critical part of cancer treatment and survivorship.

REFERENCES

Reader-Friendly Article:
Reynolds G (September 11, 2025) “A single exercise session may slow cancer cell growth, new study shows.” Washington Post. Free access via MSN: https://www.msn.com/en-us/health/other/a-single-exercise-session-may-slow-cancer-cell-growth-new-study-shows/ar-AA1Ml2oc?ocid=socialshare

Research Study:
Full publication
Bettariga F, Taaffe DR, Crespo-Garcia C, Clay TD, De Santi M, Baldelli G, Adhikari S, Gray ES, Galvão DA, Newton RU (2025) A single bout of resistance or high-intensity interval training increases anti-cancer myokines and suppresses cancer cell growth in vitro in survivors of breast cancer. Breast Cancer Res Treat, 213, 171-180. https://link.springer.com/article/10.1007/s10549-025-07772-w
PubMed Listing
https://pubmed.ncbi.nlm.nih.gov/40608178/

Strength Training through Chemotherapy: A Case Study

(Title image: Photo by Luis Reyes on Unsplash)

It used to be that people undergoing chemotherapy for cancer were told to be careful with physical activity and restrict themselves to low- and moderate-intensity exercise. Even when I was going through cancer treatment eight years ago, there was concern about how much weight I was lifting for fear of eliciting lymphedema, although by that time, exercise was more encouraged.

I am so glad that our understanding of exercise and cancer has changed! This evolution in thinking is exemplified by a case study that was recently published in the journal Lifestyle Medicine (Rolle & Crane, 2025). The lead author and PhD student in Public Health at U of Miami, LaShae Rolle (age 27), was also a competitive powerlifter who was diagnosed with stage 2B estrogen receptor-positive breast cancer in 2024.

For LaShae, exercise was an integral part of her life, something to which I can relate. She worked with her team to create training sessions that aligned appropriately with her cancer treatments which consisted of four cycles of chemo following a mastectomy.

Remarkably, by modifying her workouts as needed, LaShae was able to maintain 93% of her squat strength (408 lbs of her 441-lb one-repetition maximum (1RM)) and 87% of both her bench press (254 lbs of her 292-lb 1RM) and deadlift (430 lbs of her 497-lb 1RM). This is so impressive considering that throughout her chemo treatment she was still able to squat and deadlift over 400 lbs!

Not surprisingly, attempting to train at high-intensity on the day following her first infusion (!) resulted in severe dizziness and fatigue. By the 3rd and 4th cycles of her chemo, Rolle found that delaying intense exercises for about a week following her infusions allowed her to train more effectively. Note that her chemo cycles were three weeks apart, allowing sufficient time to recover.

Exercising Through Breast Cancer: How One Powerlifter Defied Chemotherapy with Strength Training
Yes, you can train vigorously during chemotherapy!

Why keep training during chemotherapy? There is a rapidly increasing body of research that demonstrates the critical role that physical activity plays in recovery from cancer treatment and avoiding recurrence. Unfortunately, for people who view exercise as a chore or burden, being urged to maintain an exercise program while they’re undergoing something as punishing as chemotherapy may feel like an additional punishment.

But the benefits of exercising throughout treatment, as appropriate, are irrefutable. For those who haven’t previously exercised, it’s important to begin slowly, finding physical activities that are enjoyable and rewarding, eventually ramping up the challenge to include cardiovascular exercise, strength training, balance work and flexibility training.

For those for whom workouts are an integral part of their lives, being encouraged to continue exercising as we have prior to cancer is psychologically uplifting. I’ve written in earlier posts that working out was one of the few things that I could do that gave me a sense of control in the out-of-control landscape of a cancer diagnosis. It helped me feel “normal” when I felt anything but, and that was such an important part of mentally getting through treatment.

Bottom line: Participating in your regular exercise routine during chemotherapy is doable, with modifications, and the physical activity can help you get through the treatment process. While LaShae Rolle did experience treatment side effects, she was able to work around those to limit the amount of strength she lost during chemo to an impressive degree.

REFERENCES

Research Article:

Rolle LD & Crane TE (2025) Exercising Through Breast Cancer: A Case Study on Strength Training During Active Treatment. Lifestyle Medicine, 6, e70034. https://doi.org/10.1002/lim2.70034

Reader-friendly versions:

EurekaAlert!
https://www.eurekalert.org/news-releases/1092107

University of Miami News Article
https://news.med.miami.edu/exercising-through-breast-cancer-how-one-powerlifter-defied-chemotherapy-with-strength-training/

Oncology Yoga: It’s Not Just for Relieving Stress

(Title image: Photo by Raghu Nath on Unsplash)

Last week I finished up my 75-hour yoga4cancer (y4c) Oncology Yoga teacher training (wow, that’s a mouthful!).

It was about five months of some pretty hefty lessons that spanned the cancer experience, the science of cancer, the science of yoga, the y4c methodology and lots of practice, introspection and critique. And more!

What drew me to this particular specialized yoga training was that it uses yoga as an exercise modality for true mind-body fitness, not simply to help practitioners deal with the stress and anxiety related to a cancer diagnosis, but to tap into the physical benefits of exercise in helping manage treatment-related side effects and prevent cancer recurrence.

Oncology Yoga offers a safe and effective yoga practice keeping the needs of those touched by cancer paramount.
(Photo by Junseong Lee on Unsplash)

I recently spoke with someone who represented another cancer yoga certification. She felt that cancer patients and survivors were not looking for yoga that emphasizes exercise, they wanted the stress-relieving, nurturing aspects of a yoga practice.

And there is some truth to that. I myself made the most use of the Pranayama (breath work) and Dhyana (meditation) aspects of Patanjali’s Eight Limbs of Yoga, of which Asanas (poses) are only one limb, when I was going through my own cancer experience.

But on top of that, I continued to row and lift weights throughout treatment, exercising as soon as I got over the worst days of my chemo. Same thing throughout radiation treatment. Exercise made me feel strong and “normal”, and gave me a sense of control when everything else in my life seemed out of control. This was something *I* could do for myself. It gave me agency over my life.

There is a growing body of evidence that staying physically active before, during and after cancer treatment is incredibly beneficial for survival. The evidence-based y4c Oncology Yoga methodology offers sequences that are appropriate for cancer patients and survivors, taking into account cancer-related side effects. There is ample propping to support the needs of practitioners, while still allowing them to participate in many asanas that you would find in a yoga class that isn’t cancer-oriented, taking care to avoid those that could be harmful.

The y4c methodology incorporates generous propping to allow cancer survivors to participate fully in class while keeping themselves safe.
(Photo by Samantha Sheppard on Unsplash)

No doubt, the stress-relieving aspect of yoga is immensely critical also, at a time when a cancer patient/survivor may be dealing with existential fears. There are studies being run on the impact of mindfulness and meditation as they relate to cancer and results of this research are very promising on a variety of levels.

Oncology Yoga combines the two, mind and body. Breath connects with movement in this specialized vinyasa class. The sequences help with lymphatic drainage, bone and muscle building, relieving constipation, regaining range of motion and more, all the while slowing the breath, calming the mind, lifting the spirit, bringing in a sense of grounding and self-efficacy.

I am very excited about the y4c training and am working on integrating Oncology Yoga principles into classes that I offer. My intent is to use my franticshanti.com platform to post sequences and meditations in the future. Watch this space!

8 Year Cancer-versary and Everything Hurts

(Title image: Photo by Nick Fewings on Unsplash)

This past weekend marked eight years since my breast cancer diagnosis and I recently had another oncologist appointment.

Over the years my appointments have become lighthearted. This one was not so much.

While I was concerned about the migraine auras that I’d been experiencing in the fall of last year, my oncologist had called me in November 2024 with the results of my bone density scan: I’d lost more bone and was deeper in osteopenia.

To be fair, I don’t even know how much more. It had been strange to find myself labeled with osteopenia when I had my first bone density scan over five years ago. Neither my oncologist nor I could understand it. I live a very active life with frequent workouts, including a lot of strength training. By all accounts I should have strong bones. At the time, we figured it was something to do with algorithms applied to the bone density data and my bones were actually in better shape.

Ow, ow, ow, ow, ow!
(Photo by julien Tromeur on Unsplash)

This time around, it was worse. Since the first measurement, I’d had two years of tamoxifen and one of aromatase inhibitors. That didn’t help. But all the exercise? Did it not matter? Apparently not enough.

That was frustrating on its own. But to add to that frustration, I’ve been hit with injuries. My left shoulder, my left hip and most recently my lower back.

Each one of these has taken a toll on my exercise schedule and I will likely have to seek out physical therapy for at least the shoulder. At least. The hip I have been able to manage to a certain extent. Then I tweaked my lower back rowing about two weeks ago…I kept working out, more gingerly for sure…until I managed to re-tweak my back because apparently I am incapable of leaving things well enough alone.

On the bright side, the pain in my back made me completely forget the pain in my hip. Which is not to say that there is no pain, just that it pales in comparison to back spasms.

My oncologist offered to order a spinal scan for me. I graciously declined—I’m pretty darn sure it’s just my back muscles—but his concern is valid. If I’m lifting weights with increasingly porous bones, he’s worried about spinal compression fractures.

I guess he won’t have to worry about it now. I’ve been smacked in the face with a healthy dose of humility. No, I had no intention of pulling back on my workouts, but doing so is unavoidable. The amount of weight I can lift without injury has steadily decreased (injury by injury) and with this last helping of pain, I have to face reality. I need to completely rehaul my workouts along with my expectations.

Just sittin’ and chillin’ and dreamin’ of strong bones.
(Photo by Anne Nygård on Unsplash)

Perhaps most importantly, I need to not view this as a failure on my part. Because while I knew that eventually that day would come, I was not prepared to actually accept that it was here. I was still trying to “work my way back up” to where I was before, even when I knew that it was unrealistic.

After all, I remind myself, the fact that I need to adopt a slightly gentler approach to my workouts is a sign of success: the reason I need to be more careful now is because I have survived this long past my diagnosis. That’s not a punishment or a capitulation. It is, in fact, a blessing and a luxury that many cancer patients don’t have.

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What now? I am resistant to bone-building bisphosphonates at this time, for a variety of reasons (hello, side effects). I want to see if I can stop/slow the bone loss on my own. I have the exercise part down, no problem. But to be completely honest, my dietary intake of calcium was very low. I had every intention of supplementing with calcium after my first bone density scan, but got spooked by the potential for heart issues.

Since then, I’ve learned about the importance of Vitamin K2 and the Japanese fermented bean natto, which has loads of it and makes sure calcium gets to the bones instead of the heart. I’ve re-started the calcium supplements with a daily serving of the fermented stuff. You could say, I’ve become an aficio-natto.

And now that I am forced to back off the intense exercise, I have the opportunity to focus on mobility work, stretching and rehabilitation as I discover what body parts are going to need the attention of a physical therapist. We’ll see how this new approach to fitness works.

The Gift of Self-Care

(Title image: Photo by Ben White on Unsplash)

I’m popping in here with a little reminder to practice self-care over the remainder of this holiday season and springboard that care into the new year.

“I have had no time for self-care with everything going on!”, you may protest, but then, what do you imagine self-care to be?

If you believe commercials, it’s drinking red wine in the bathtub, eating ice cream from the container, using a face mask and getting your nails done at a salon. All while chanting, “BECAUSE I’M WORTH IT!”

In general, anyone who is perpetuating that type of “self-care” is trying to sell you something.

Journaling is an effective form of self-care and doesn’t require an expensive journal or pen, no matter what someone tries to sell you.
(Photo by Sixteen Miles Out on Unsplash)

Here are less expensive options that I feel align more closely with the true meaning of self-care:
* pausing during the day to take a few mindful breaths;
* noticing where you are (“Right now, I am in the kitchen doing the dishes, feeling the warm water and slipperiness of the soap on my hands”) to help calm racing thoughts;
* making a decision to choose a more nourishing food, eating slowly, savoring each bite;
* decreasing/eliminating alcohol — substitute a drink that looks festive (sprig of rosemary or a skewered piece of fruit added to sparkling water);
* staying consistent with exercise, or if time is squeezed, sticking in extra movement whereever you can (like doing 5 squats every time you go to the bathroom or a short yoga session right before bed);
*practicing gratitude, and if that’s hard, just finding something to appreciate.

And of course, taking time for a brief meditation whenever you can.

I think you get the idea.

Holiday self-care is not about buying things. It’s not about practicing an Instagram or TikTok version of indulgence. There are no photos to post and you don’t need a manual for it to be beneficial.

It is taking a break to drop down out of your thoughts and into the present moment. Be kind to your body and mind, get enough sleep and exercise to make yourself feel good. And importantly: release expectations of what you think the holiday should look like, how people should act, what you should be able to accomplish, even how you should feel about it. Find appreciation for whatever is going well.

I wish you a peaceful, positive start to 2025!

Aging Muscle: After Cancer Treatment and Menopause [PHOTOS]

(Title image: Photo by Samuel Girven on Unsplash)

This is a reality check to demonstrate how, even with the greatest of intentions and planning, coupled with a serious love of exercise, you can’t turn back time.

And that’s okay.

But first, the comparison. Taken from this previous post, here’s a photo right before I started chemotherapy for triple-positive breast cancer, April 27, 2017:

April 27, 2017: I was exercising with a vengeance

After finishing chemo, radiation and Herceptin, AND after two years of estrogen-lowering Tamoxifen and a year into Letrozole, I’d lost some muscle even though I was lifting as heavy as I could.

This photo is from December 11, 2020:

December 11, 2020: Still exercising with a vengeance, but…

While I was still working out hard, endocrine therapy and menopause took their toll on my progress. Interestingly, estrogen is not simply a “feminizing” hormone; in women, it also helps preserve both muscle and bone mass. Menopause puts the breaks on estrogen production.

This becomes worrying as we age because less estrogen means weaker muscles which can lead to a greater risk of falls and chance of bone fractures. Endocrine therapy, which is designed to decrease the estrogen in the body in order to lessen the recurrence risk of hormone-sensitive breast cancer, adds to the problem.

And more than seven years after the top photo, this was taken today before posting, September 23, 2024:

September 23, 2024: New phone, different lighting (sorry!), more wrinkles, same moles. I’m working hard just to keep what I have, but loss is inevitable.

I’m still lifting but the entire landscape of my workout routines has changed. I have to give myself more recovery time between strength training sessions. I am much more susceptible to injuries—seriously, I can tweak something by turning or stretching out in a weird way. I have neuropathy in my feet which makes getting up on my toes (such as in plank or doing lunges) painful.

We recently had an intense heat wave: for a week the temperature inside our apartment didn’t fall below 80F degrees, and during the day it climbed as high as 95F degrees (again, INSIDE our apartment). I managed to work out through a chunk of that week, but the heat eventually got to me. And recovering from that took almost another week.

So, the spirit is willing but the flesh is barely managing at times.

However, there is an upside to being 58 years old with a lifetime of fitness experience. I still love working out. Even tough training sessions are manageable because they feel like an awesome accomplishment, and I feel bouyed afterwards.

Even on the days that I don’t do a formal workout, I make sure that I’m moving as much as I can. Fitness is an integral part of my life, even though it looks different now than it did seven years ago. In the post that I reference earlier, at the very bottom I wrote about how yoga was becoming a larger part of my life.

And that’s continued. Through my yoga teacher training in 2022 and upcoming yoga4cancer advanced training starting in January 2025, this direction feels so right for me.

While I don’t plan to give up my gym sessions anytime soon, yoga has given me a path to physical and mental fitness as I age. I am gradually moving into a more meditative approach to exercise that is less about intensity and more about staying healthy by integrating mind and body.

White Paper: “Yoga Interventions for Cancer Patients and Survivors”

(Title image: Photo by Raimond Klavins on Unsplash)

I’ve been writing a lot lately about using yoga to mitigate cancer therapy-related side effects.

In this post, I want to bring your attention to the white paper entitled, “Yoga Interventions for Cancer Patients and Survivors” [Important: this links to the download page on the yoga4cancer website, *not* directly to the pdf itself]. It’s an evidence-based review of research regarding the benefits of a yoga practice in coping with negative side effects that afflict cancer patients and survivors, followed by recommendations for teaching yoga to this population.

This 24-page document (quoted directly from the paper’s abstract) “(1) provides a summary of research on the benefits of yoga for cancer patients and survivors, (2) highlights the most beneficial components of yoga for cancer survivors, (3) identifies barriers and solutions to the creation of accessible, evidence-based yoga programming, and (4) offers guidelines for developing yoga programs that best meet the unique needs of cancer patients and survivors.” [Again, this links to the download page.]

The white paper is written in non-technical language, distilling the research down into a form that doesn’t require a scientific background to understand. Additionally, editions are available in Spanish and Japanese, both available on the download page beneath the English version.

If you’d rather not download, you can read the English version below (or click the “download” button underneath the paper for a pdf):

yoga-interventions-for-cancer-patients-and-survivors_white-paperDownload

“Moving Through Cancer”: A Short Film from ACSM

(Title image: Photo by guille pozzi on Unsplash)

I’ve been coming across a lot of interesting–and hopefully useful– videos. The one I’m posting here is presented by the nonprofit Fund for Sustainable Tomorrows and the American College of Sports Medicine, the latter being the organization through which I received my personal trainer certification almost 16 years ago.

This is a 20-minute film with a hopeful message!

The film, narrated by former Olympic figure skater and cancer survivor Scott Hamilton, showcases the stories of how survivors are using exercise to make themselves feel better and increase their chances for survival. It also shows how our knowledge about physical activity’s benefits during cancer treatment has increased, and the programs that have been created to help cancer patients become and stay active.

It’s amazing to see how within a decade or two the attitude about cancer and exercise has changed. Whereas individuals undergoing cancer treatment used to be told to rest as much as possible, now it’s understood that exercising through your treatment is one of the best ways to not only minimize associated side effects but also decrease the chances of cancer recurrence.

For me, exercising during my treatment was a way to feel normal when everything else felt out of control.

The current recommendation is aerobic activity for 150-300 minutes per week along with twice weekly resistance training sessions. And it’s best to do both types of exercise for a well-rounded program, if you can manage it.

But the most important thing to remember is that no matter what you do, doing something is better that doing nothing. Research has discovered the existence of myokines, hormones that are produced in the tissue of skeletal muscles. They are released during muscular contractions and seem to have anti-cancer properties, slowing cancer growth and spread. That is very exciting news!

Of course, exercise is not a cure, and there is no guarantee that if you are an avid exerciser you won’t get cancer or won’t have it recur. However, there’s a very good chance that physical activity will make you feel better and help you continue with life-saving treatments.

As E. Ronald Hale, MD, MPH, Medical Director of Radiation Oncology at Kettering Health states (from the video), “The best cancer treatment in the world is useless if you can’t get through the cancer treatment.” The side effects from cancer therapies can be debilitating, but getting out and moving will improve your quality of life and help you finish your treatment.

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It’s worth mentioning that the number of exercise professionals who have had additional training in working with cancer patients is growing, which means that cancer-informed trainers and yoga teachers are becoming easier to find. Now it’s the insurance companies that need to get on board.

yoga4cancer: Bringing the Benefits of Yoga to Cancer Patients and Survivors [VIDEOS]

(Title image: Photo by Zoltan Tasi on Unsplash)

In February 2022, I started a yoga teacher training program with a singular goal: to eventually teach yoga to cancer patients and survivors.

With its mix of physical postures (asanas), breathwork (pranayama) and meditation, yoga is ideal for someone going through the traumatic experience that cancer can be. Yoga can provide enough physical exertion to count as moderate exercise and the ability to help the practioner calm their mind, things that are so important for improving cancer treatment outcomes. However, classes must be designed carefully and taught thoughtfully.

Yoga4Cancer Q&A for Cancer Patients and Survivors (Yoga Alliance on YouTube)

Keep in mind, yoga teachers were yoga practitioners first. Many of them got really good at the practice, developed great flexibility and balance and gained respect for the tradition of yoga. But that doesn’t automatically make them appropriate yoga teachers for cancer patients, who need an instructor that understands the nuances of what cancer is and how treatment affects us.

A yoga teacher and breast cancer survivor by the name of Tari Prinster addressed that need by creating yoga4cancer (y4c), “an evidence-informed Oncology Yoga method tailored to address the specific physical and emotional needs left by the cancer and cancer treatments. The approach matches breath and movement to stimulate the immune system, improve flexibility & strength, reduce anxiety and boost overall well-being” (from the y4c website).

I’m planning to begin the y4c advanced 75-hour certification program (see informational video here) either later this year or early next. I’ve been so impressed by y4c’s emphasis on understanding the unique situation that cancer patients and survivors are in–it’s not just your garden variety beginner yoga class with “also for cancer patients” dressing. The program is well-thought out and comprehensive, and I’m so excited to embark on this next leg of moving closer to my teaching goal.

In the meantime, here is a selection of videos created by Tari and her instructors that are specifically geared for the mental and physical needs of cancer patients and survivors:

Yoga4Cancer Oncology Yoga for Cancer Related Fatigue (Yoga Alliance on YouTube)
Yoga4Cancer Yoga for Bone Loss (Yoga Alliance on YouTube)
Yoga4Cancer Yoga for Range of Motion (Yoga Alliance on YouTube)
Yoga4Cancer.com Yoga for Anxiety (Yoga Alliance on YouTube
yoga4cancer.com Yoga for Lymphedema (Yoga Alliance on YouTube)
yoga4cancer.com Yoga for Constipation (Yoga Alliance on YouTube)

Enjoy!

Effects of Diet and Exercise on Chemotherapy Tolerance and Efficacy: Research

(Title image: Photo by Hermes Rivera on Unsplash)

Many cancer patients complain of feelings of helplessness after their diagnosis, and I can certainly relate to that. As a result, I’m particularly interested in research that explores whether patients can gain control over the success of their treatments.

The most recent study I’ve come across includes breast cancer patients undergoing treatment at Yale and Dana Farber Cancer Centers.

This study appeared in the Journal of Clinical Oncology (Sanft et al., 2023). Researchers examined the effect of diet and exercise on “relative dose intensity” (RDI), which is the relationship between the amount of chemotherapy delivered to the patient compared to the standard amount prescribed. Low RDI means that there was a reduction in the chemotherapy the patient received and is generally associated with a poorer outcome. Dose reductions result from the patient’s difficulty in tolerating the drug.

The researchers also looked for “pathologic complete response” (pCR), which is “the lack of all signs of cancer in tissue samples removed during surgery or biopsy after treatment with radiation or chemotherapy” (definition from cancer.gov). This was for women receiving neoadjuvant chemotherapy, which is chemotherapy administered prior to surgery.

Yep, once again we come back to diet and exercise, even during chemo.
(Photo by Yulissa Tagle on Unsplash)

The subjects of this study were women recently diagnosed with stage I-III breast cancer, who either received the “usual care” or a diet and exercise intervention. Those in the intervention group received nutritional counseling with a focus on a plant-based diet. The physical activity included counseling and support for maintaining a home-based exercise program that included strength training (2x/week) and brisk walking (150 min/week of moderate intensity or 75 min/week of vigorous intensity).

What the research confirmed first was that the subjects in the intervention group were able to increase their exercise and diet quality, which showed that it was feasible to make lifestyle improvements even in the midst of chemotherapy.

However, in this study, the RDI for both groups (“usual care” and diet & exercise intervention) ended up being similar, but also quite high, which meant that women in both groups completed most of their treatment. The researchers noted that the study should be re-run with patients who were at greater risk of not being able to complete all their chemo to see how much of an effect improved diet and exercise would have, especially since exercise has been shown in other studies to have a positive effect on patient outcomes.

But a striking difference was seen for women receiving neoadjuvant (prior to surgery) chemotherapy in that the rates of pCR (disappearance of cancer in the tissues) were 53% for women in the intervention group versus 28% for women receiving usual care. That suggests that the intervention enabled the chemotherapy to be more effective.

There are many physical activities you can choose from–clifftop not required.
(Photo by Sigmund on Unsplash)

The researchers stated the following in summarizing their study: “Given that pCR is an accepted predictor of recurrence and mortality, our findings could provide oncologists with a supportive care intervention that affects the ability to potentially improve survival outcomes” (Sanft et al., 2023, J Clin Oncol). And this is very good news indeed.

The take-home message here is not surprising, and it’s good advice for life in general: no matter what your current lifestyle, prioritizing a healthier diet (emphasis on whole foods, plant-based, less processing, etc.) and engaging in regular cardiovascular and strength training exercise will improve your quality of life. It is always worth the effort.

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REFERENCE:
Sanft et al. (2023) Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. J Clin Oncol, 41: 5285–5295. https://doi.org/10.1200%2FJCO.23.00871. [This paper is Open Access and can also be found in PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691793/]