Sweatin’ for Myokines [RESEARCH]

(Title image: Photo by Annemiek Smegen on Unsplash)

Following up on my “Exercise and Cancer Cells” post from September 2025, here is another paper by the same authors that was published this month that offers more evidence about the importance of exercise for cancer survivors.

This study by Bettariga et al. (2026, Med Sci Sports Exer) investigated what effect different types of exercise would have on the production of myokines in breast cancer survivors. Why myokines? Because myokines are chemicals released during a muscular contraction. Once in the bloodstream they have various effects on the human body, but the most important for our discussion is that some myokines have been shown to decrease the growth of cancer cells, although the mechanism by which they do that is still unclear.

The study participants, all breast cancer survivors, were assigned to either strength (resistance) training or HIIT groups.
(Photo by Robert Stump on Unsplash)

This study compared resistance training against high-intensity interval training, or HIIT. For twelve weeks, twenty-eight breast cancer survivors engaged in either resistance training or HIIT, three days per week. Exercise was performed at moderate-to-high levels of intensity, which means that the participants were challenged by the activities.

At the end of the twelve weeks, regardless of which exercise group the subjects were in, the cancer-busting myokines circulating in their bloodstreams had increased by as much as 15%; both resistance training and HIIT were equally effective. Furthermore, when serum taken from the study participants was applied to metastatic (in this case, triple-negative) cancer cells in the lab, there was a 22-25% reduction in the growth of the cells.

These are excellent results. While the study group (28 participants) was quite small and additional research with a larger set of subjects should be done, the effect of exercise was striking.

As mentioned above, the exercise was medium-to-high intensity. What exactly this means for each individual will vary, as intensity is specific to the exerciser and depends a lot on their current fitness levels. For this study, none of the participants had exercised in the previous three months, so they weren’t gym rats to start out with. Their results were still significant.

Everyone has different abilities. Begin at your own starting point and take it from there.
(Photo by LOGAN WEAVER | @LGNWVR on Unsplash)

As I’ve said in previous posts, being diagnosed with cancer leaves you feeling out of control and powerless about your own body. It can feel like things are happening to you and there’s little you can do about it. This is one way that you can effect a positive change and improve your chances of recurrence-free survival, and it is something over which you have control.

The take-home message? There is a constantly-expanding body of scientific literature that supports maintaining as high a level of physical activity as you personally can, while still respecting the limitations that your body may have. Start slowly, increase intensity gradually, keep going…and don’t ever stop.

REFERENCES

Reader-Friendly Article:
Bettariga F (January 6, 2026) “How Exercise May Suppress Cancer Growth.” Active Voice|ACSM. https://acsm.org/active-voice-how-exercise-may-suppress-cancer-growth/

Research Study:
Full publication (Abstract available without journal access)
Bettariga F, Taaffe DR, Crespo-Garcia C, Clay TD, De Santi M, Baldelli G, Adhikari S, Gray ES, Galvão DA, Newton RU (2026) Effects of Resistance versus High-Intensity Interval Training on Myokines and Cancer Cell Suppression in Breast Cancer Survivors: A Randomized Trial. Med Sci Sports Exer, 58, 1-9.
https://journals.lww.com/acsm-msse/abstract/2026/01000/effects_of_resistance_versus_high_intensity.1.aspx
PubMed Listing
https://pubmed.ncbi.nlm.nih.gov/40903011/

Oncology Yoga: It’s Not Just for Relieving Stress

(Title image: Photo by Raghu Nath on Unsplash)

Last week I finished up my 75-hour yoga4cancer (y4c) Oncology Yoga teacher training (wow, that’s a mouthful!).

It was about five months of some pretty hefty lessons that spanned the cancer experience, the science of cancer, the science of yoga, the y4c methodology and lots of practice, introspection and critique. And more!

What drew me to this particular specialized yoga training was that it uses yoga as an exercise modality for true mind-body fitness, not simply to help practitioners deal with the stress and anxiety related to a cancer diagnosis, but to tap into the physical benefits of exercise in helping manage treatment-related side effects and prevent cancer recurrence.

Oncology Yoga offers a safe and effective yoga practice keeping the needs of those touched by cancer paramount.
(Photo by Junseong Lee on Unsplash)

I recently spoke with someone who represented another cancer yoga certification. She felt that cancer patients and survivors were not looking for yoga that emphasizes exercise, they wanted the stress-relieving, nurturing aspects of a yoga practice.

And there is some truth to that. I myself made the most use of the Pranayama (breath work) and Dhyana (meditation) aspects of Patanjali’s Eight Limbs of Yoga, of which Asanas (poses) are only one limb, when I was going through my own cancer experience.

But on top of that, I continued to row and lift weights throughout treatment, exercising as soon as I got over the worst days of my chemo. Same thing throughout radiation treatment. Exercise made me feel strong and “normal”, and gave me a sense of control when everything else in my life seemed out of control. This was something *I* could do for myself. It gave me agency over my life.

There is a growing body of evidence that staying physically active before, during and after cancer treatment is incredibly beneficial for survival. The evidence-based y4c Oncology Yoga methodology offers sequences that are appropriate for cancer patients and survivors, taking into account cancer-related side effects. There is ample propping to support the needs of practitioners, while still allowing them to participate in many asanas that you would find in a yoga class that isn’t cancer-oriented, taking care to avoid those that could be harmful.

The y4c methodology incorporates generous propping to allow cancer survivors to participate fully in class while keeping themselves safe.
(Photo by Samantha Sheppard on Unsplash)

No doubt, the stress-relieving aspect of yoga is immensely critical also, at a time when a cancer patient/survivor may be dealing with existential fears. There are studies being run on the impact of mindfulness and meditation as they relate to cancer and results of this research are very promising on a variety of levels.

Oncology Yoga combines the two, mind and body. Breath connects with movement in this specialized vinyasa class. The sequences help with lymphatic drainage, bone and muscle building, relieving constipation, regaining range of motion and more, all the while slowing the breath, calming the mind, lifting the spirit, bringing in a sense of grounding and self-efficacy.

I am very excited about the y4c training and am working on integrating Oncology Yoga principles into classes that I offer. My intent is to use my franticshanti.com platform to post sequences and meditations in the future. Watch this space!

“Moving Through Cancer”: A Short Film from ACSM

(Title image: Photo by guille pozzi on Unsplash)

I’ve been coming across a lot of interesting–and hopefully useful– videos. The one I’m posting here is presented by the nonprofit Fund for Sustainable Tomorrows and the American College of Sports Medicine, the latter being the organization through which I received my personal trainer certification almost 16 years ago.

This is a 20-minute film with a hopeful message!

The film, narrated by former Olympic figure skater and cancer survivor Scott Hamilton, showcases the stories of how survivors are using exercise to make themselves feel better and increase their chances for survival. It also shows how our knowledge about physical activity’s benefits during cancer treatment has increased, and the programs that have been created to help cancer patients become and stay active.

It’s amazing to see how within a decade or two the attitude about cancer and exercise has changed. Whereas individuals undergoing cancer treatment used to be told to rest as much as possible, now it’s understood that exercising through your treatment is one of the best ways to not only minimize associated side effects but also decrease the chances of cancer recurrence.

For me, exercising during my treatment was a way to feel normal when everything else felt out of control.

The current recommendation is aerobic activity for 150-300 minutes per week along with twice weekly resistance training sessions. And it’s best to do both types of exercise for a well-rounded program, if you can manage it.

But the most important thing to remember is that no matter what you do, doing something is better that doing nothing. Research has discovered the existence of myokines, hormones that are produced in the tissue of skeletal muscles. They are released during muscular contractions and seem to have anti-cancer properties, slowing cancer growth and spread. That is very exciting news!

Of course, exercise is not a cure, and there is no guarantee that if you are an avid exerciser you won’t get cancer or won’t have it recur. However, there’s a very good chance that physical activity will make you feel better and help you continue with life-saving treatments.

As E. Ronald Hale, MD, MPH, Medical Director of Radiation Oncology at Kettering Health states (from the video), “The best cancer treatment in the world is useless if you can’t get through the cancer treatment.” The side effects from cancer therapies can be debilitating, but getting out and moving will improve your quality of life and help you finish your treatment.

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It’s worth mentioning that the number of exercise professionals who have had additional training in working with cancer patients is growing, which means that cancer-informed trainers and yoga teachers are becoming easier to find. Now it’s the insurance companies that need to get on board.